Although Grammer pointed out that "there’s been no premise that has come along that has the necessary fire," he did say that they're still working on cracking the story.
Grammer went on, explaining that Dr. Fraiser Crane has to have "sorted out something that he hadn’t had sorted out previously."
"A lot of us are quite committed to the concept that you would never try to redo what we once had," Grammer added. Joining him on the panel was none other than David Hyde Pierce, Jane Leeves and Peri Gilpin, who played Niles, Daphne and Roz respectively.
As to whether Niles, Daphne and Roz were returning, Grammer made his feelings pretty clear on the subject. "There has been some discussions; nothing is planned; There is nothing set in stone. In my own personal approach to what I’ve discussed with other people is that I wouldn’t want to do it without these guys."
The final series of 'Frasier' aired in 2004, and the final episode of that series saw Frasier leave behind KACL and his talk show for a new life in Chicago with his latest girlfriend, played by Laura Linney. Niles and Daphne, meanwhile, had their first child whilst Marty finally remarried, meaning that he was to move out of Frasier's apartment.
The episode, titled 'Goodnight Seattle', is widely considered to be one of the greatest final episodes of a sitcom. In total, the series won five consecutive Emmys for Outstanding Comedy Series, whilst the cast and crew picked up 32 Emmys across its 11-year run.
So, yeah, that's going to be hard to top.