As we told you earlier in the week, The Late Late Show were looking for your pet problems ahead of tonight's show as Ryan will be joined by Channel 4's Supervet Noel Fitzpatrick. The Laois man will be having a crack at diagnosing the ailments of these pets, as well as talking about the pioneering surgeries that have made him famous.
Joining him will be Grand National Winner trainer Mouse Morris and his son Jamie fresh from their victory last week at Aintree. They will be chatting to Ryan about the race itself but also the mixed emotions they felt winning following the tragic death of Mouse's son Tiffer last year.
Also on the show, journalist Emily Hourican will be talking about sharing her cancer diagnosis with readers of the Sunday Independent and why she chose to be open about her battle with the disease.
While British-Asian Muslim stand-up comedian Shazia Mirza will join Ryan to talk about her new show "The Kardashians Made Me Do It".
We will also meet four of the best designs from Junk Kouture, a national contest which encourages second level students to create couture designs and works of wearable art using everyday items that would normally find their way into the bin. The judges of the competition are none other than Vogue Williams and Louis Walsh too... hopefully Louis can fill us in on all these rumours of his X Factor return.
Finally, there will be music from Luka Bloom, We Banjo 3 and YouTube sensation Bry.
Want to know who's on The Graham Norton Show tonight? Head here.