Grey's Anatomy fans will be well aware that Sandra Oh's Dr Cristina Yang is due to depart from Seattle Grace at the end of Season 10 but not before having a huge pow-wow with one rather unexpected main character.

SPOILER ALERT: Do not read ahead if you'd prefer to avoid Season 10 spoilers. This one is particularly juicy too.

"A beautiful storyline is coming up about the friendship between Cristina and Meredith, and I love it," Oh told Entertainment Weekly. "I love it because it’s challenging and it's like a real growing pain that they go through." she said. We still can't believe it's now Owen, being honest. We're so used to that story at this stage.

"At the beginning of the season they have quite different lives" Oh explained. "Meredith is married and has two children, and Cristina, who has now parted ways from Owen Hunt (Kevin McKidd), is a non-parent and is very focused on her work and life, so that causes a riff"

She does love the new storyline though, citing the pair's upcoming situation as something the viewers will most definitely be able to relate to. "My best friend I’ve known since I was six and we’ve been best friends since we were in junior high and lived on the same street" she said. "There have been times that we have issues in our relationship. You come to a point where you feel distance from your relationship, and things are brought up and that you have to weather. Like any good long-term relationship, you have to put in the time and your love will sustain."

Speaking of love sustaining, will Shonda Rhimes have enough love for Dr Yang to keep her alive off-screen? "Please!" Oh exclaimed, "I would like my character to remain alive!"