This time round, Louis is returning to America with the three documentaries set to be titled Murder in Milwaukee, Opiate City and one with the working title of Sex Trafficking Houston.
The first, Murder in Milwaukee, focuses on the racial tensions sparked by two police shootings in the city, with Louis speaking to local residents and the police force.
Opiate City examines how the USA's crackdown on over-prescribing drugs has lead to an epidemic of heroin abuse.
While Sex Trafficking Houston follows the lives of women working in the sex industry along with the dynamic between pimps and prostitutes. The Texas city is considered the country's hub of sexual exploitation and trafficking.
Speaking to The Independent, Louis said: "I immerse myself in some of the most dysfunctional and disturbing aspects of American society. They combine hard-hitting actuality with intimate interviews.
"I have been granted access to the police in several states; I've got to know the people affected by crime; and I've also spent time with the perpetrators of crime, with the idea of understanding the causes of it, both on a systemic level and also in a very personal way."
BBC Two's Channel Editor, Patrick Holland, also said: "This is so exciting. It is always a real event to have a new series from Louis on BBC Two. This trilogy promises to be hugely timely and challenging, it has never been more important to engage with the forces shaping modern America."
The documentaries will be shown on BBC2 later in the year.