After 12 years on the show, Holly Willoughby has departed ITV's 'Celebrity Juice'.

Willoughby was one of the original team captains on the show with Fearne Cotton, who also left the show two years ago. Confirming the news on Instagram via several behind-the-scenes-photos, Willoughby thanked ITV and Leigh Francis, as well as the production staff and audience members, describing the show as "fantastic chaos."

"Over the years the production team has changed, however to anyone lucky enough to have worked on the show, they will know that we really do have the best time, it’s never felt like work and always been to me like a night out," Willoughby wrote.

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Thank you @celebjuiceofficial for 12 years of fantastic chaos... I can’t quite believe what we’ve done and how quick that time has gone. Thank you to you all for watching..we’ve always had the loudest and best audiences. Also a huge thank you to @itv2 for believing in the show in the first place and for all of your support...Over the years the production team has changed, however to anyone lucky enough to have worked on the show, they will know that we really do have the best time, it’s never felt like work and always been to me like a night out... Thank you for all your ingenious ideas and hard work... all good things must come to an end and nothing lasts forever... It’s time for me to hand over my team captain seat to some lucky lucky person... whoever that is, know you are about to get one of the best jobs in telly working with one of comedies finest... @keithlemon ... Where to begin... I remember starting this journey with you and saying ‘I think this might work’... my goodness me it did... three friends, you me and @fearnecotton ... and that is what is at the heart of it.. friendship... I love the bones of you Lemon! Thank you for making me laugh for twelve years... I’ll be back as a guest and just to make sure someone is keeping you in check... if I don’t see you through a week or next week or the week after... know you are always in my heart... ❤️

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As of now, no replacement has been announced for Willoughby and speculation is rife as to who it will be. Fearne Cotton was replaced as team captain by Mel B from the Spice Girls, who herself was often lampooned on 'Bo' Selecta' by Leigh Francis.

Willoughby will continue as team captain up until the end of the season, which is currently in progress on ITV2 and next airs this Tuesday at 10PM.