The actor and Thirty Seconds to Mars singer took to the stage to remember his friends who both sadly committed suicide earlier this year.
"MTV asked me to come here to say a few words about Chester and the late, great Chris Cornell, two artists that I had the absolute pleasure of touring with," Leto said.
He went on to speak movingly about their talents as musicians, their legacy and their families
The Oscar winner concluded by saying- "If there is anyone out there who is watching this tonight, who feels there is no hope, hear me now: you are not alone. The absolutely biggest breakthroughs in life lie just beyond the darkest days.”
Watch the clip in full here: