Julee Cruise, the singer of 'Falling' which soundtracked David Lynch's iconic 'Twin Peaks', has died aged 65.

The singer had been battling autoimmune lupus disease since 2018, and her husband, author Edward Grinnan, said "she left this realm on her own terms."

"No regrets, she is at peace," he added.

Cruise had worked with the B-52's, and Grinnan said that working with the band "was the happiest time of her performing life."

"I played her the B-52's song 'Roam' during her transition. Now she will roam forever. Rest in peace, my love," he wrote.

Prior to the success of 'Twin Peaks', Cruise had worked with director David Lynch and composer Angelo Badalamenti, with the trio first working together on the 1986 film 'Blue Velvet'.

Cruise became a frequent David Lynch collaborator in the wake of 'Blue Velvet', with 'Falling' becoming the theme song for 'Twin Peaks'.

While the show used an instrumental version of the track, David Lynch and Angelo Badalamenti wrote lyrics for the track, which Cruise memorably sung.

The show quickly became a cultural phenomenon in the early 1990s, with 'Falling' topping the charts in Australia and becoming a top 10 chart hit in Ireland and the UK.

A 2017 Little White Lies article called the Cruise version of the song "iconic in the purest sense of the word."

Cruise made an appearance as herself in the show's 2017 revival and also appeared in the 1992 film 'Twin Peaks: Fire Walk With Me', with her one-scene role a memorable moment in David Lynch's critically divisive film.

Discussing her working relationship with David Lynch in 2018, Cruise said "it’s like I’m his little sister: you don’t like your older brother telling you what to do. David’s foppish. He can have these tantrums sometimes. And have you ever seen his temper? Anybody can look funny when they get mad. But I love him.”

In a 2014 interview with Rolling Stone, Cruise noted her influence on female singers in the modern era.

The article noted "these days, Cruise’s floating, soft-focus vocals and Badalamenti’s quivering layers of synthesizer echo in the music of artists like Lana Del Rey," and Cruise was inclined to agree.

Discussing modern female singers, Cruise noted "They sing like sexy baby girls - they all have their own personality.”