On New Year's Eve in 2020, an unknown virus spreads from Wuhan to other places. The number of patients is increasing at an explosive rate. People are horrified by the powerful and highly infectious virus.The unprecedented survival crisis causes grief and panic. A little-known infectious disease hospital, Jiang Han, is chosen as a designated hospital. Zhang Jingyu, president of the hospital, suffers from Amyotrophic Lateral Sclerosis (ALS). Together with the Respiratory Department director, young interns and head nurse of the ICU, Zhang faces numerus challenges and accidents while he perseveres to save patients at the frontline.