The first season of Weeds premiered on August 8, 2005, and consisted of 10 episodes.

The second season of Weeds premiered on August 14, 2006, and consisted of 12 episodes.

The third season of Weeds premiered on August 13, 2007, and consisted of 15 episodes.

On November 5, 2007, Showtime ordered 13 new episodes for a fourth season of Weeds. It started on Monday, June 16, 2008 and concluded on Monday, September 15, 2008. The season opener "Mother Thinks the Birds are After Her" was the last episode with "Little Boxes" as the theme song. The opening credits of subsequent episodes, after a recap of previous episodes, begin with a video title card unique to each episode. For the second episode of the season, for example, a highway sign reads "Weeds -- Created by Jenji Kohan" — the embedded text used for all title cards since the show's inception. Each title card also has a prop or part of the setting that refers to a plot element in the episode. Some part of the title card morphs into a marijuana leaf. In the highway sign example, a downward arrow designating a lane becomes a slightly larger pot leaf. Silas and Shane are aged 17 and 13 respectively. However, Silas turns 18 at the end of the season.

The fifth season of Weeds consisted of 13 episodes. Its debut, on June 8, 2009, attracted 1.2 million viewers, with a rerun on the same night adding another 500,000 viewers for a cumulative 1.7 million. The season finale episode premiered on Monday, August 31, 2009, averaging 1.3 million viewers, up versus season 4's finale that averaged 1 million.

The sixth season of Weeds premiered on Monday, August 16, 2010 at 10ET/PT on the television cable network Showtime, and consisted of 13 episodes.

The seventh season of Weeds premiered on June 27, 2011 at 10 E/9 C on the television cable network Showtime, and consisted of 13 episodes. As the season picks up, Nancy has spent three years in prison and now lives in a strictly monitored halfway house in New York City, where the family meet after the other Botwins have spent three years in Denmark.

The eighth and final season of Weeds premiered on July 1, 2012, and featured 13 episodes, bringing the series total to 102. It marks the return of the show's theme song, "Little Boxes". Creator Jenji Kohan revealed that cover versions of the song would be used during the opening credits and confirmed that Ben Folds and the Mountain Goats would be featured artists. Kohan also confirmed that the song would be covered in a duet by Steve Martin and series regular Kevin Nealon, who each sang and played the banjo. Series co-star Hunter Parrish also provided a cover version for the season's tenth episode. The final two episodes of the season aired back to back as a one-hour series finale, which was the series' first and only one hour show in its eight-year run.