After a 1995 sorority pledge gone wrong, someone is out for vengeance when a college campus is rattled by a series of murders at the twentieth anniversary of the crime.

The second season picks up years after the murderous events at Kappa House. Dean Munsch purchases an abandoned hospital with a haunted past. After recruiting surgeons as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels. They delve deep into the most fascinating and bizarre medical cases, as a new and terrifyingly funny mystery begins once again.