"La querida del Centauro" chronicles the life of Yolanda, an attractive and intelligent prisoner, that becomes the mistress of one of the most important drug traffickers of Mexico, Benedictino García, alias "El Centauro". This relationship, which inside the prison will give much power to Yolanda, will end up becoming her worst nightmare when she manages to be released thanks to Gerardo, a shrewd detective whose last years have been dedicated to the fight against drug trafficking. With El Centauro in hiding, Gerardo decides to use Yolanda as bait in an operation that will take them to the hiding place of El Centauro.