The 51-year-old actor - who was diagnosed with Parkinson's disease in 1991 - will come out of his early retirement to star in an upcoming Sony Pictures Television comedy in 2013 which is inspired by his own life.
He is teaming up with Easy A director Will Gluck and writer Sam Laybourne, who has worked on Cougar Town and Arrested Development, Vulture reports.
For those not familiar with Michael J Fox for some reason, he rose to fame in 1980s sitcom Family Ties before making his big screen debut in Back to the Future as time-travelling teen Marty McFly.
The actor then starred in the hugely popular political sitcom Spin City, but quit his television career (much to Charlie Sheen's joy, as he picked up the lead in Spin City thereafter) in 2000 to focus on his health and set up the Michael J. Fox Foundation to help find a cure for the degenerative condition.
He has made several minor guest appearances on TV shows since, however, including Rescue Me, Curb Your Enthusiasm and The Good Wife. Michael also had a recurring role on comedy Boston Legal.
The star told ABC News in May that his new drug regimen is allowing him to take on more roles because his tics are under control.