In the American West during the 1850s, gunfighter brothers Eli and Charlie Sisters are employed by a rich businessman, known as the Commodore. He hires them to kill Hermann Warm, who eventually reveals that he is en route to find gold using a chemical formula of his own invention. Western, starring John C Reilly, Joaquin Phoenix, Jake Gyllenhaal, Riz Ahmed and Rutger Hauer in one of his final film roles