The award-winning host continues his anarchic talk show and is joined this week by Hollywood star Sigourney Weaver, who talks about her new film Paul; TV's favourite physicist (because he's pretty and used to be the keyboardist in a popband), Professor Brian Cox; and comedienne Sandi Toksvig. You might recall her as being one of the two females allowed on Who's Line Is It Anyway. No, not the tall one who went on to play Minty's girlfriend in EastEnders, the other one. There's also music from US pop sensation Sugarland.