Louis Theroux visits Central Valley, California - home to some of the most impoverished rural towns in America, where crystal-meth addiction is among the most prolific in the USA. In Fresno, Louis finds a community ravaged by this cheap and highly addictive drug; it's hard to find anyone whose life hasn't been touched by it in one way or another. As he infiltrates the town, Louis comes face to face with meth abuse as addicts invite him into their homes. He becomes surrounded by the madness of daily addiction and the meth-addled confusion which is breaking this society apart. Louis sees its impact through the eyes of the local police force and meets Diane and Karl, a couple who have sustained their marriage, despite 25 years of meth addiction and the loss of the custody of their five children. He also sees the extraordinary challenges faced by a centre which deals with a whole range of issues: from old timers, who repeatedly return to rehab programmes; to young meth-addicted families; and babies who are born, hooked, to mothers who are trying to care for them while trying to kick their own habit. This is mandatory viewing as you don't know when it's going to land on our doorsteps.