Following their disappointing defeat in the Stade de France two weeks ago, Ireland will have to something they haven't managed since 2010 to keep their slim hopes of three in a row alive. Beat England in Twickenham. Joe Schmidt has decided to give youth a chance by calling in Josh van der Flier and Stuart McCloskey to make their test debuts. England have two wins from two under new coach Eddie Jones but they were far from commanding in their victories against Scotland and Italy. This fixture is always one of the biggest of the campaign for both sides. (Kick Off: 4.50pm)