Four drug-addicted people go into a downward spiral with devastating effects on their families. A woman takes diet pills in a bid to look slim for her appearance on a TV show, her heroin-addict son and his friend turn to crime to pay for their addiction, and one of the boys' girlfriends faces her own battle with narcotics. Darren Aronofsky's drama, based on the novel by Hubert Selby Jr and starring Jared Leto, Ellen Burstyn, Marlon Wayans and Jennifer Connelly.