Pleasure is vital for our survival - without it we wouldn't eat or have sex, and would soon die out as a species. But how does pleasure work and what gives us the most pleasure in life? In an attempt to find out, Michael Mosley - who doesn't exactly look like you're average purveyor of pleasure, learns how the hottest chilli in the world creates euphoria in the brain, why parents have an overwhelming surge of love for their newborn child and what happens if you turn your own wedding into a chemistry experiment. He also exposes himself to painful experiments, highlighting the dangers of life without discomfort and discovering how far he is prepared to go to experience one of the world's most pleasurable highs. Will he be able to overcome enormous pain and stress in order to experience one of the biggest pleasure kicks in the world?