England v Italy
England v Italy (Kick-off 4.45pm). The fourth round of fixtures continues with this encounter at Twickenham, where England start as overwhelming favourites to prevail. This is the 25th meeting between the nations since they first met in 1991 and England maintain a 100% record in that time. That statistic seems unlikely to come under threat this year, as Eddie Jones continues to build his squad ahead of the World Cup, while Italy have failed to make any great strides recently and sit in their customary place at the bottom of the table.