This comedy thriller is about three friends whose relationships are tested and lives are changed when one of them is diagnosed with cancer. In this opening episode, Charlie discovers he has Hodgkin's lymphoma just as he reconnects with Joel, a friend from sixth form. The prognosis is good as it is its early stages and Charlie is young and healthy. However, he refuses chemotherapy due to his suspicions of drugs and modern medical treatments. Joel, another friend from school called Tess, and Joel’s new girlfriend Nadia try to get Charlie to change his mind. Chris Geere, Tom Riley, Jessica Regan and Lizzy Caplan (Janis Ian from Mean Girls) star.