Six school friends meet up for a fourth of July celebration on a remote island off the Washington coast for a weekend of fun and partying. But the good times quickly turn into a nightmare when they unknowingly take a new bio-active drug containing a virus that causes fits of psychotic rage. Only one girl, Brie, doesn't take the drug and she alone must fight to stay alive as her friends slowly turn into bloodthirsty cannibals. Trapped on the island, Brie must endure the unimaginable and fight for her life.