Talash tells the story of three close friends - Saleem, Tania and Khurrum - who have recently graduated as medical doctors and are involved in setting up a medical camp in rural Tharparkar. When Khurrum leaves for his village and promises to return in five days, concern grows when days turn to months. Saleem and Tania begin their search (or 'talash') for their friend while deep down inside, Tania battles with her feelings for Khurrum, unaware Saleem has feelings for her.