America is a lost nation. When an epidemic of vampirism strikes, humans find themselves on the run from vicious, feral beasts. Cities are tombs and survivors cling together in rural pockets, fearful of nightfall. When his family is slaughtered, young Martin is taken under the wing of a grizzled, wayward hunter whose new prey are the undead. Simply known as Mister, the vampire stalker takes Martin on a journey through the locked-down towns of America's heartland, searching for a better place while taking down any bloodsuckers that cross their path.