What do you get when you cross toxic waste with a bunch of exotic spiders? ... Eaten! ... The residents of a rural mining town discover that an unfortunate chemical spill has caused hundreds of little spiders to mutate overnight to the size of SUVs. And they're hungry! When the alarm is sounded, it's then up to mining engineer Chris McCormack and Sheriff Sam Parker to mobilize an eclectic group of townspeople, including the Sheriff's young son, Mike, her daughter, Ashley and paranoid radio announcer Harlan Griffith and Deputy Pete Willis into battle against the bloodthirsty eight-legged beasts.