Jess and Chester wake up one morning after a night of partying and the nightmare begins: Their stash is gone, Jesse's car is gone, their girlfriends - the twins - are mad and the boys can't remember anything from the night before. They set out on a whirlwind journey to figure out what happened. As Jesse and Chester retrace their steps they discover that the night before they had- and lost - a suitcase full of cash, they met a gorgeous gender-challenged stripper and six sexy alien women, and now they are caught up in the middle of an intergalactic war with the fate of the universe in their hands!