Risk-averse Reuben Feffer, whose best-laid plans for life and love careen wildly off-track when his bride dumps him on their honeymoon for a muscle-bound scuba instructor. Stunned, humiliated and in the grip of acute indigestion, Reuben plans to play it safer than ever. But a chance adventure with an adventure-craving childhood friend named Polly, shoots him into a whirlwind of extreme sports, spicy foods, ferrets, salsa dancing and living in the moment.