Isabel (Michelle Williams) has dedicated her life to working with the children in an orphanage in Calcutta. Theresa (Julianne Moore) is the multimillionaire head of a media company who lives with her handsome artist husband (Billy Crudup) and their two adorable twin boys in New York. When word comes to Isabel of a mysterious and generous grant for the financially struggling orphanage, she must travel to New York to meet the benefactor Theresa in person. And when Isabel is spontaneously invited to Theresa's daughter's wedding, Isabel discovers a connection to Theresa that takes her on an unexpected journey into her own past.