The Star Trek actor is joining the A-list cast checking in to Hotel Artemis.
Drew Pearce, who wrote Iron Man 3 and Mission Impossible: Rogue Nation, is making his directorial debut on the movie and also wrote the script.
The action is set in the near future and takes place in an underground Los Angeles hospital where the city's criminals are being treated.
Also down to star alongside Quinto are Jodie Foster who plays a nurse that finds out one of her patients is trying to assassinate another.
Jeff Goldblum, Sterling K. Brown, Jenny Slate, Charlie Day and Dave Bautista will make up the cast.