Limitless director Neil Berger was recently announced as the man who would be replacing David O'Russell on video game adaptation Unchartered, and had this to say to Craveoline.com about the film:

"We're beginning from scratch and going back to the videogame ... it's really one of the most cinematic videogames, and one that has really developed characters. So, you know, there's a lot of cool, really intense things that, if they work for the film's story, I want to use them." So it looks like The O'Russell version which was apparently very different from the game, has been completely scraped. When asked about the possible casting of Nathan Fillion in the main role of Drake, he said: I think he's a good actor, [but] I think there's a lot of really good actors who don't even look like (Nathan Drake) who could play it. Where we are right now is that we're literally starting from scratch on the screenplay, and I think that once we finish it, then we'll go to actors and see who's available and who's right for the parts. Whenever that happens."

That pretty much confirms that Mark Wahlberg isn't attached to the film either anymore, and that we're probably a while off seeing it, if at all.